
Mefloquine hydrochloride
CAS No. 51773-92-3
Mefloquine hydrochloride( Mefloquin hydrochloride )
Catalog No. M14802 CAS No. 51773-92-3
A quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine; inhibits autophagy and has been recognized as a potential target for cancer therapy.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
25MG | 27 | In Stock |
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50MG | 38 | In Stock |
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100MG | 49 | In Stock |
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200MG | 65 | In Stock |
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500MG | 88 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameMefloquine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine; inhibits autophagy and has been recognized as a potential target for cancer therapy.
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DescriptionA quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine; inhibits autophagy and has been recognized as a potential target for cancer therapy.Bacterial Infection Approved(In Vitro):Mefloquine hydrochloride selectively inhibits prostate cancer (PCa) cell growth with an IC50 of ~10 μM. Mefloquine hydrochloride also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS generation.Mefloquine hydrochloride (10 μM)-mediated ROS simultaneously downregulated Akt phosphorylation and activated ERK, JNK and AMPK signaling in PC3 cells.Mefloquine shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 of 1.28 μM, IC90 of 2.31 μM, and IC99 of 4.39 μM in VeroE6/TMPRSS2 cells. Mefloquine inhibits viral entry after viral attachment to the target cell.(In Vivo):Mefloquine hydrochloride (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice.
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In VitroMefloquine hydrochloride selectively inhibits prostate cancer (PCa) cell growth with an IC50 of ~10 μM. Mefloquine hydrochloride also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS generation.Mefloquine hydrochloride (10 μM)-mediated ROS simultaneously downregulated Akt phosphorylation and activated ERK, JNK and AMPK signaling in PC3 cells.Mefloquine shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 of 1.28 μM, IC90 of 2.31 μM, and IC99 of 4.39 μM in VeroE6/TMPRSS2 cells. Mefloquine inhibits viral entry after viral attachment to the target cell.
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In VivoMefloquine hydrochloride (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice. Animal Model:Young 3.5-month-old and old 21-month-old female C57BL/6 mice Dosage:5 mg/kg Administration:Intraperitoneal injection; daily; 14 days Result:Reversed the lower vertebral cancellous bone volume and bone formation in old mice.
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SynonymsMefloquin hydrochloride
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PathwayAutophagy
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TargetAutophagy
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Recptorhemozoin
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Research AreaInfection
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IndicationBacterial Infection
Chemical Information
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CAS Number51773-92-3
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Formula Weight414.7731
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Molecular FormulaC17H17ClF6N2O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CCN[C@H](C1)[C@H](C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl
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Chemical Name4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1), (αS)-rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sharma N, et al. Cancer Lett. 2012 Dec 30;326(2):143-54.
2. Shin JH, et al. Neurosci Lett. 2012 May 2;515(2):162-7.
3. Shin JH, et al. Neurosci Lett. 2012 May 2;515(2):162-7.
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